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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN2 All Species: 15.45
Human Site: S204 Identified Species: 30.91
UniProt: P17706 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17706 NP_002819.1 415 48473 S204 F K V R E S G S L N P D H G P
Chimpanzee Pan troglodytes XP_512196 415 48479 S204 F K V R E S G S L N P D H G P
Rhesus Macaque Macaca mulatta XP_001118328 448 50818 P250 D F G V P E S P A S F L N F L
Dog Lupus familis XP_547685 388 45298 L194 P E S P A S F L N F L F K V R
Cat Felis silvestris
Mouse Mus musculus Q06180 406 47342 C204 F K V R E S G C L T P D H G P
Rat Rattus norvegicus P35233 363 42217 T169 E N I N S G E T R T I S H F H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508429 545 61767 S205 F K V R E S G S L S S D H G P
Chicken Gallus gallus O13016 434 50316 S203 F K V R E S G S L N P E Y G P
Frog Xenopus laevis NP_001086910 468 54192 H212 Q N G P A V V H C S A G I G R
Zebra Danio Brachydanio rerio NP_997819 393 45640 S199 F L F K V R E S G S L G M E Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W0G1 548 62086 D222 K F L Q Q V R D S G C L S R D
Honey Bee Apis mellifera XP_392429 495 55903 Q215 N F L T D V R Q S G T L D Q N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 69.1 86.9 N.A. 88.6 79.7 N.A. 41.4 53 54.2 57.5 N.A. 31.9 40.2 N.A. N.A.
Protein Similarity: 100 99.7 75.8 88.9 N.A. 92.5 84 N.A. 53.2 70 67 71.5 N.A. 46.9 55.5 N.A. N.A.
P-Site Identity: 100 100 0 6.6 N.A. 86.6 6.6 N.A. 86.6 86.6 6.6 13.3 N.A. 0 0 N.A. N.A.
P-Site Similarity: 100 100 13.3 13.3 N.A. 86.6 20 N.A. 93.3 100 13.3 26.6 N.A. 20 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 17 0 0 0 9 0 9 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 9 9 0 9 0 0 0 0 % C
% Asp: 9 0 0 0 9 0 0 9 0 0 0 34 9 0 9 % D
% Glu: 9 9 0 0 42 9 17 0 0 0 0 9 0 9 0 % E
% Phe: 50 25 9 0 0 0 9 0 0 9 9 9 0 17 0 % F
% Gly: 0 0 17 0 0 9 42 0 9 17 0 17 0 50 0 % G
% His: 0 0 0 0 0 0 0 9 0 0 0 0 42 0 9 % H
% Ile: 0 0 9 0 0 0 0 0 0 0 9 0 9 0 0 % I
% Lys: 9 42 0 9 0 0 0 0 0 0 0 0 9 0 0 % K
% Leu: 0 9 17 0 0 0 0 9 42 0 17 25 0 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % M
% Asn: 9 17 0 9 0 0 0 0 9 25 0 0 9 0 9 % N
% Pro: 9 0 0 17 9 0 0 9 0 0 34 0 0 0 42 % P
% Gln: 9 0 0 9 9 0 0 9 0 0 0 0 0 9 9 % Q
% Arg: 0 0 0 42 0 9 17 0 9 0 0 0 0 9 17 % R
% Ser: 0 0 9 0 9 50 9 42 17 34 9 9 9 0 0 % S
% Thr: 0 0 0 9 0 0 0 9 0 17 9 0 0 0 0 % T
% Val: 0 0 42 9 9 25 9 0 0 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _